A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry <i>In Vitro</i> and <i>In Vivo</i>
Catherine Adam, Thomas L. Bray, Ana M. Pérez‐López, Ee Hong Tan, Belén Rubio‐Ruíz, Daniel J. Baillache, Douglas R. Houston, Mark J. Salji, Hing Y. Leung, Asier Unciti‐Broceta
Abstract
efficacy studies in a xenograft colon cancer model served to prove, for the first time, that orally administered prodrugs can be locally converted to active drugs by intratumorally inserted Pd implants.
Topics & Concepts
ProdrugIn vivoChemistryAnabolismPharmacologyBioavailabilityCatabolismAntimetaboliteDrugPharmacokineticsOral administrationChemotherapyIn vitroToxicityMetabolismBiochemistryMedicineInternal medicineBiologyBiotechnologyOrganic chemistryBiochemical and Molecular ResearchColorectal Cancer Treatments and StudiesCancer Treatment and Pharmacology