Organo-catalyzed C2,3–H aminochalcogenation of indoles with secondary (aliphatic) amines
Xiaoxiang Zhang, Chenrui Liu, Yingying Zhang, Fang Shen, Wanxing Wei, Zhuan Zhang, Taoyuan Liang
Abstract
A direct C2,3–H difunctionalization of indoles with unactivated amines facilitated by the organo-chalconium catalyst generated through the reaction of iodine and chalconium reagents has been developed.
Topics & Concepts
ChemistryCatalysisMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions