A proteome-wide atlas of drug mechanism of action
Dylan C. Mitchell, Miljan Kuljanin, Jiaming Li, Jonathan G. Van Vranken, Nathan J. Bulloch, Devin K. Schweppe, Edward L. Huttlin, Steven P. Gygi
Topics & Concepts
ProteomeComputational biologyProteomicsDrug discoveryMechanism of actionSmall moleculeBiologyHistoneChemical spaceDihydrofolate reductaseSystems pharmacologyDrugBioinformaticsBiochemistryPharmacologyEnzymeIn vitroGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysAdvanced Proteomics Techniques and Applications