Allicin, a dietary trpa1 agonist, prevents high fat diet-induced dysregulation of gut hormones and associated complications
Pragyanshu Khare, Neha Mahajan, Dhirendra Singh, Vibhu Kumar, Vijay Kumar, Priyanka Mangal, Ravneet K. Boparai, Adam Gesing, Sanjay Kumar Bhadada, Shyam Sundar Sharma, Kanthikiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Abstract
Our experiments have found a significant role for gut hormones and alterations in their release patterns as central to HFD-induced complications which might be successfully prevented by TRPA1 activation through TRPA1 agonist ARGJ.
Topics & Concepts
EndocrinologyGut floraInternal medicineHormoneInflammationGhrelinDiet-induced obeseMetabolic syndromeGlucose homeostasisAgonistReceptorBiologyMedicineDiabetes mellitusInsulin resistanceImmunologyIon Channels and ReceptorsBiochemical Analysis and Sensing TechniquesPostharvest Quality and Shelf Life Management