Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies
Ramar Sivaramakarthikeyan, Shunmugam Iniyaval, Vadivel Saravanan, Wei‐Meng Lim, Chun‐Wai Mai, Chennan Ramalingan
Abstract
has been reflected while performing molecular docking studies (-8.65 kcal/mol). The outcomes of the investigation expose that these hybrids could be used as effective intermediates to construct more potent biological agents.
Topics & Concepts
PyrazoleBenzimidazoleChemistryMoietyHybridStereochemistryDiclofenac SodiumDocking (animal)Structural motifCombinatorial chemistryBiological activityRational designStructure–activity relationshipBiochemistryIn vitroOrganic chemistryBiologyGeneticsBotanyChromatographyMedicineNursingSynthesis and biological activityBioactive Compounds and Antitumor AgentsSynthesis and Biological Evaluation