Comparing Current Noise in Biological and Solid-State Nanopores
Alessio Fragasso, Sonja Schmid, Cees Dekker
Abstract
solid-state nanopores provide the highest SNR, due to the large currents at which they can be operated and the relatively low noise at high frequencies. However, the real game-changer for many applications is a controlled slowdown of the translocation speed, which for MspA was shown to increase the SNR > 160-fold. Finally, we discuss practical approaches for lowering the noise for optimal experimental performance and further development of the nanopore technology.
Topics & Concepts
NanoporeNanotechnologyNoise (video)BiomoleculeBottleneckSolid-stateNanopore sequencingCurrent (fluid)Materials scienceComputer sciencePhysicsElectrical engineeringEngineeringChemistryEngineering physicsArtificial intelligenceEmbedded systemGenomeBiochemistryImage (mathematics)GeneNanopore and Nanochannel Transport StudiesIon-surface interactions and analysisFuel Cells and Related Materials