Global Transcriptional Regulators Fine-Tune the Translational and Metabolic Efficiency for Optimal Growth of Escherichia coli
Mahesh S. Iyer, Ankita Pal, Sumana Srinivasan, Pramod R. Somvanshi, K. V. Venkatesh
Abstract
Cellular proteome allocation in response to environmental or internal perturbations governs their eventual phenotypic outcome. This entails striking an effective balance between amino acid biosynthesis by metabolic proteins and its consumption by ribosomes.
Topics & Concepts
Escherichia coliProteomeRibosomeProtein biosynthesisBiologyPhenotypeAdaptation (eye)Amino acidMetabolic pathwayCell biologyTranslational regulationBiosynthesisTranslation (biology)BiochemistryChemistryMetabolismGeneMessenger RNARNANeuroscienceRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyEnzyme Structure and Function