Construction of Fe-doped ZIF-8/DOX nanocomposites for ferroptosis strategy in the treatment of breast cancer
Yuyu Zhong, Zhaoxi Peng, Yanqiong Peng, Bo Li, Ying Pan, Qin Ouyang, Hiroshi Sakiyama, Mohd. Muddassir, Jianqiang Liu
Abstract
a synergistic effect between apoptosis and ferroptosis. The mechanism of action of DOX@7FZ was further verified using hematoxylin and eosin staining and immunohistochemical staining of Bcl-2 and GPX-4. These remarkable characteristics of DOX@7FZ may inspire further advancements in the treatment of breast cancer.
Topics & Concepts
ApoptosisNanocompositeMaterials scienceBreast cancerDopingCancerCancer researchCancer cellCancer treatmentNanotechnologyMedicineInternal medicineOptoelectronicsChemistryBiochemistryFerroptosis and cancer prognosisMicroRNA in disease regulationNanoplatforms for cancer theranostics