COVID-19 and Inborn Errors of Immunity
Ottavia M. Delmonte, Riccardo Castagnoli, Luigi D. Notarangelo
Abstract
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evolution of COVID-19 in IEI patients. This review analyzes clinical outcomes following SARS-CoV-2 infection, as well as response to COVID-19 vaccines in patients with IEI.
Topics & Concepts
ImmunityCoronavirus disease 2019 (COVID-19)Immune systemImmunologyMedicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyVirologyPathologyDiseaseOutbreakInfectious disease (medical specialty)Immunodeficiency and Autoimmune DisordersKawasaki Disease and Coronary ComplicationsParvovirus B19 Infection Studies