Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as Sirt1 inhibitors
Nikil Purushotham, Mrityunjay Singh, Paramesha Bugga, Vasantha Kumar, Sharad Wakode, S. Banerjee, Boja Poojary, Shailendra Asthana
Abstract
in Sirt1, which could be used as a starting lead to design more potent and selective sirtuin inhibitors as a potential anticancer molecule.
Topics & Concepts
Combinatorial chemistryChemistryStereochemistrySirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism