Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay in the Human Mouth
Yuan Liu, Yue Huang, Dongyeop Kim, Zhi Ren, Min Jun Oh, David P. Cormode, Anderson T. Hara, Domenick T. Zero, Hyun Koo
Abstract
free-radical generation. Further analysis indicates that the targeting mechanism involves interactions of FerIONP with pathogen-specific glucan-binding proteins, which have a minimal effect on commensal streptococci. In addition, we demonstrate that FerIONP can detect pathogenic biofilms on natural teeth via a facile colorimetric reaction. Our findings provide clinical evidence and the theranostic potential of catalytic nanoparticles as a targeted anti-infective nanomedicine.
Topics & Concepts
BiofilmFerumoxytolStreptococcus mutansHydrogen peroxideChemistryNanomedicineMicrobiologyAntimicrobialIron oxide nanoparticlesNanoparticleAntimicrobial chemotherapyDental plaqueBacteriaNanotechnologyBiologyMedicineBiochemistryMaterials scienceGeneticsMagnetic resonance imagingRadiologyOral microbiology and periodontitis researchAdvanced Nanomaterials in CatalysisDental Health and Care Utilization