β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis
Yuchen Pan, Jingman Li, Xiaoyu Xia, Jiali Wang, Qi Jiang, Jingjing Yang, Huan Dou, Huaping Liang, Kuanyu Li, Yayi Hou
Abstract
Background: Innate immune memory, also termed "trained immunity", is thought to protect against experimental models of infection, including sepsis. Trained immunity via reprogramming monocytes/ macrophages has been reported to result in enhanced inflammatory status and antimicrobial activity against infection in sepsis. However, a safe and efficient way to induce trained immunity remains unclear.
Topics & Concepts
ImmunitySepsisSuperparamagnetismIron oxide nanoparticlesNanoparticleGlucanNanotoxicologyChemistryNanotechnologyImmune systemImmunologyMedicineMaterials scienceBiochemistryPhysicsMagnetic fieldMagnetizationQuantum mechanicsImmune responses and vaccinationsCOVID-19 Impact on ReproductionGut microbiota and health