Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies
Wissam H. Faour, Ali Choaib, Elio Issa, Francesca El Choueiry, Khodor Shbaklo, Maryline Alhajj, Ramy Touma Sawaya, Zeina Harhous, Eman Alefishat, Moni Nader
Abstract
The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.