A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 signaling
Ailin Yang, Qi Wu, Zhongdong Hu, Shaoping Wang, Yufan Tao, An-Mei Wang, Yixuan Sun, Xiulian Li, Long Dai, Jiayu Zhang
Topics & Concepts
Cancer researchCyclin-dependent kinase 2Signal transductionPI3K/AKT/mTOR pathwayProtein kinase BBiologyPharmacologyKinaseCell biologyProtein kinase ACancer, Hypoxia, and MetabolismComputational Drug Discovery MethodsBioactive Compounds and Antitumor Agents