Unraveling the mechanism of enantio-controlling switches of an alcohol dehydrogenase toward sterically small ketone
Yingying Jiang, Ge Qu, Xiang Sheng, Feifei Tong, Zhoutong Sun
Abstract
Unraveling the mechanism of “Switches” (positions 294 and 295) that specifically control the inversion of product chirality by dry and wet experimental analysis.
Topics & Concepts
Steric effectsMechanism (biology)KetoneChemistryInversion (geology)Alcohol dehydrogenaseAlcoholChirality (physics)StereochemistryOrganic chemistryPhilosophyBiologyPhysicsChiral perturbation theoryEpistemologyParticle physicsStructural basinNambu–Jona-Lasinio modelPaleontologyPionMicrobial Metabolic Engineering and BioproductionBiochemical Acid Research StudiesEnzyme Catalysis and Immobilization