Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8+ T cells in early clinical stages of chronic lymphocytic leukemia
Hadiseh Rezazadeh, Mojgan Astaneh, Mohsen Tehrani, Hadi Hossein‐Nataj, Ehsan Zaboli, Ramin Shekarriz, Hossein Asgarian‐Omran
Topics & Concepts
CD8Cytotoxic T cellDegranulationChronic lymphocytic leukemiaImmunologyBlocking antibodyCD28Immune systemAntibodyTIGITCancer researchMedicineBiologyLeukemiaIn vitroInternal medicineReceptorBiochemistryChronic Lymphocytic Leukemia ResearchCAR-T cell therapy researchCancer Immunotherapy and Biomarkers