Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials
Maura Malpetti, Renaud La Joie, Gil D. Rabinovici
Abstract
Several biomarkers have emerged in the past few decades to quantify pathologic brain changes related to Alzheimer disease (AD). In particular, PET radiotracers that bind selectively to amyloid-β plaques and tau neurofibrillary tangles have advanced AD research and drug development by enabling the
Topics & Concepts
AtrophyDiseaseAlzheimer's diseaseMedicineNeuroscienceAmyloid (mycology)Drug trialClinical trialTau pathologyPathologyPsychologyAlzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments