Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45– TER119–Erythroid and Lymphoid Progenitors
Kazuhito Gotoh, Yuya Kunisaki, Soichi Mizuguchi, Daiki Setoyama, Kentaro Hosokawa, Hisayuki Yao, Yuya Nakashima, Mikako Yagi, Takeshi Uchiumi, Yuichiro Semba, Jumpei Nogami, Koichi Akashi, Fumio Arai, Dongchon Kang
Abstract
TNCs exhibited impaired mitochondrial oxidation that consequently led to inactivation of mTORC1 signaling, which is essential for erythropoiesis. These findings uncover the importance of mitochondria, especially at the stage of TNCs during erythropoiesis, suggesting that dysregulation of mitochondrial protein synthesis is a cause of anemia and B-lymphopenia with an unknown pathology.
Topics & Concepts
ErythropoiesisHaematopoiesisIneffective erythropoiesisBiologyCell biologyMyeloidBone marrowMitochondrionProgenitor cellStem cellErythroblastHematopoietic stem cellImmunologyAnemiaInternal medicineMedicineAcute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationErythrocyte Function and Pathophysiology