Uracil derivatives as HIV-1 capsid protein inhibitors: design, <i>in silico</i>, <i>in vitro</i> and cytotoxicity studies
Deepthi Ramesh, Amaresh Kumar Mohanty, Anirban De, Balaji Gowrivel Vijayakumar, Aiswarya Sethumadhavan, Suresh Kumar Muthuvel, Maheswaran Mani, Tharanikkarasu Kannan
Abstract
The paper describes the design, synthesis, computational and biological validation of a series of novel uracil derivatives as effective HIV capsid protein inhibitors.
Topics & Concepts
PharmacophoreUracilChemistryCapsidCytotoxicityIn silicoIC50StereochemistryIn vitroCombinatorial chemistryLead compoundBiochemistryDNAGeneHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and Interventions