G protein subunit alpha i2's pivotal role in angiogenesis
Chaowen Bai, Lu Lu, Jia-nan Zhang, Chengyu Zhou, Yi-chao Ni, Keran Li, Jin Yao, Xiaozhong Zhou, Changgong Lan, Cong Cao
Abstract
Our study highlights a critical role for Gαi2 in NFAT activation, endothelial cell activation and angiogenesis, offering valuable insights into potential therapeutic strategies for modulating these processes.
Topics & Concepts
NFATAngiogenesisEndothelial stem cellCell biologySmall hairpin RNABiologyMolecular biologyVascular endothelial growth factor AChemistryVascular endothelial growth factorCancer researchCell cultureTranscription factorGene knockdownIn vitroBiochemistryGeneticsVEGF receptorsGeneCell Adhesion Molecules ResearchRetinal Diseases and TreatmentsSystemic Lupus Erythematosus Research