Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4
Felipe de Camargo Ribeiro, Juliana Campos Junqueira, Jéssica Diane dos Santos, Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Shashank Shukla, Beth Burgwyn Fuchs, Anita Shukla, Eleftherios Mylonakis
Abstract
Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and it is necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeted for local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food additive, with a probiotic and investigated its antifungal activity against Candida albicans .