Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28
Bing Chen, Yuting Sang, Xiaojin Song, Dong Zhang, Lijuan Wang, Wenjing Zhao, Yiran Liang, Ning Zhang, Qifeng Yang
Abstract
The present study demonstrates that CAFs promote breast cancer progression and metastasis via exosomal miR-500a-5p and indicate that inhibiting CAF-derived miR-500a-5p is an alternative modality for the treatment of breast cancer.
Topics & Concepts
Cancer researchMetastasisBreast cancerCancerCell growthCancer cellCellCancer metastasisMedicineOncologyBiologyInternal medicineGeneticsExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases