Metabolomic Profiling and Toxicokinetics Modeling to Assess the Effects of the Pharmaceutical Diclofenac in the Aquatic Invertebrate <i>Hyalella azteca</i>
Qiuguo Fu, Andreas Scheidegger, Endre Laczkó, Juliane Hollender
Abstract
. Combining the TK processes and metabolomics provides complementary insights and thus a better mechanistic understanding of the effects of diclofenac in aquatic invertebrates.
Topics & Concepts
Hyalella aztecaDiclofenacBiotransformationToxicokineticsBioaccumulationPharmacologyChemistryMetabolomeEnvironmental chemistryToxicodynamicsToxicityBiologyMetabolomicsBiochemistryAmphipodaChromatographyEcologyPharmacokineticsCrustaceanOrganic chemistryEnzymePharmaceutical and Antibiotic Environmental ImpactsMetabolomics and Mass Spectrometry StudiesAquaculture disease management and microbiota