Synthesis of spirosuccinimides <i>via</i> annulative cyclization between <i>N</i>-aryl indazolols and maleimides under rhodium(<scp>iii</scp>) catalysis
Ju Young Kang, Won Gun An, Suho Kim, Na Yeon Kwon, Taejoo Jeong, Prithwish Ghosh, Hyung Sik Kim, Neeraj Kumar Mishra, In Su Kim
Abstract
-aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.
Topics & Concepts
RhodiumCatalysisArylChemistryCombinatorial chemistryMoleculeReaction mechanismStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms