Direct Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant
Li Wang, Alexander R. White, Wei Chen, Zhanhong Wu, David A. Nicewicz, Zibo Li
Abstract
Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.
Topics & Concepts
Photoredox catalysisOxidizing agentChemistryCombinatorial chemistryPeroxideHydrogen peroxidePhotocatalysisCatalysisPhotochemistryOrganic chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods