Amino acid primed mTOR activity is essential for heart regeneration
Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic-Mex, Elisa C. Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez K.A. Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola‐Baker
Abstract
. Through a multi-omics approach with cellular validation we identify metabolic and mitochondrial changes during the first week of regeneration. These data suggest that regeneration of zebrafish myocardium is driven by metabolic remodeling and reveals a unique metabolic regulator, TOR-primed state, in which zebrafish and mammalian cardiomyocytes are regeneration competent.
Topics & Concepts
PI3K/AKT/mTOR pathwayRegeneration (biology)ChemistryAmino acidCell biologyBiochemistryBiologySignal transductionCongenital heart defects researchPancreatic function and diabetesMitochondrial Function and Pathology