Long COVID: Long-Term Impact of SARS-CoV2
Huda Makhluf, Henry Madany, Kenneth Kim
Abstract
Four years post-pandemic, SARS-CoV-2 continues to affect many lives across the globe. An estimated 65 million people suffer from long COVID, a term used to encapsulate the post-acute sequelae of SARS-CoV-2 infections that affect multiple organ systems. Known symptoms include chronic fatigue syndrome, brain fog, cardiovascular issues, autoimmunity, dysautonomia, and clotting due to inflammation. Herein, we review long COVID symptoms, the proposed theories behind the pathology, diagnostics, treatments, and the clinical trials underway to explore treatments for viral persistence, autonomic and cognitive dysfunctions, sleep disturbances, fatigue, and exercise intolerance.
Topics & Concepts
DysautonomiaCoronavirus disease 2019 (COVID-19)MedicinePandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakIntensive care medicineChronic fatigue syndromeAffect (linguistics)PsychologyPhysical therapyOutbreakVirologyInternal medicineDiseaseInfectious disease (medical specialty)CommunicationLong-Term Effects of COVID-19Fibromyalgia and Chronic Fatigue Syndrome ResearchNeuroinflammation and Neurodegeneration Mechanisms