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Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors

Wenwen Nie, Yang Lu, Chenghao Pan, Jian Gao, Mengxin Luo, Jiaming Du, Jiao Wang, Peihua Luo, Hong Zhu, Jinxin Che, Qiaojun He, Xiaowu Dong

2022Bioorganic Chemistry15 citationsDOI

Topics & Concepts

Fibroblast growth factor receptor 4ChemistryCovalent bondApoptosisHepatocellular carcinomaFibroblast growth factor receptorBiochemistryReceptorCancer researchFibroblast growth factorBiologyOrganic chemistryFibroblast Growth Factor ResearchCancer-related gene regulationPI3K/AKT/mTOR signaling in cancer
Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors | Litcius