Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs
Lee Call, Tiffany L. Molina, Barbara J. Stoll, Gregory Guthrie, Shaji Chacko, Jogchum Plat, Jason L. Robinson, Sen Lin, Caitlin Vonderohe, Mahmoud A. Mohammad, Dennis Kunichoff, Stephanie Cruz, Patricio E. Lau, Muralidhar H. Premkumar, Jon Nielsen, Zhengfeng Fang, Oluyinka O. Olutoye, Thomas Thymann, Robert A. Britton, Per Torp Sangild, Douglas G. Burrin
Abstract
XIVa, and higher abundance of Enterobacteriaceae than those of IL and ENT pigs. Differences in lipid and microbial-derived compounds were also observed in colon metabolite profiles. These results indicate that multi-component lipid emulsions prevent cholestasis and restore enterohepatic bile flow in association with gut microbial and metabolomic changes. We conclude that sustained bile flow induced by multi-component lipid emulsions likely exerts a dominant effect in reducing bile acid-sensitive gram-positive bacteria.