Beta-blocker and calcium-channel blocker toxicity: current evidence on evaluation and management
Charlotte Goldfine, Andrew Troger, Timothy B. Erickson, Peter R. Chai
Abstract
Beta-blocker and calcium-channel blocker overdoses are associated with severe morbidity and mortality; therefore, it is important to recognize and appropriately treat individuals with toxicity. The most common clinical findings in toxicity are bradycardia and hypotension. In addition to supportive care and cardiac monitoring, specific treatment includes administration of calcium salts, vasopressors, and high-dose insulin euglycaemia treatment. Other advanced treatments (e.g. ECMO) may be indicated depending on the severity of toxicity and specific agents involved.
Topics & Concepts
ToxicityCalcium channel blockerBradycardiaMedicineBeta blockerCardiac toxicityCalcium channelPharmacologyCalciumAnesthesiaInternal medicineHeart failureHeart rateBlood pressurePoisoning and overdose treatmentsCardiac Arrest and ResuscitationCardiovascular Syncope and Autonomic Disorders