Anthocyanin-rich fraction from Thai berries interferes with the key steps of lipid digestion and cholesterol absorption
Netima Chamnansilpa, Pattamaporn Aksornchu, Sirichai Adisakwattana, Thavaree Thilavech, Kittana Mäkynen, Winai Dahlan, Sathaporn Ngamukote
Abstract
values of 90.6-181.7 μg/mL and 288.7-455.0 μg/mL, respectively. Additionally, all extracts could bind primary and secondary bile acids (16.4-36.6%) and reduce the solubility of cholesterol in artificial micelles (53.0-67.6%). Interestingly, TPE was the most potent extract on interfering the key steps of lipid digestion among the tested extracts. In addition, TPE (0.10-0.50 mg/mL) significantly reduced the cholesterol uptake into Caco-2 cells in a concentration-dependent manner. These results demonstrate a new insight into the role of anthocyanin-rich Thai berry extract on interfering the key steps of lipid digestion and absorption.