Metal-dependent activity control of a compact-sized 8–17 DNAzyme based on metal-mediated unnatural base pairing
Yusuke Takezawa, Lingyun Hu, Takahiro Nakama, Mitsuhiko Shionoya
Abstract
ions, showing good metal responsiveness. Since it has been challenging to modify compactly folded DNAzymes without losing their activity, this study demonstrates the utility of the metal-mediated artificial base pairing to create stimuli-responsive functional DNAs.
Topics & Concepts
DeoxyribozymePairingMetalBase metalBase (topology)ChemistryBase pairNanotechnologyMaterials sciencePhysicsDNAMetallurgyBiochemistryMathematicsCondensed matter physicsOrganic chemistrySuperconductivityMathematical analysisWeldingAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms