Intramolecular Oxidative Coupling between Unactivated Aliphatic C–H and Aryl C–H Bonds
Yang Liao, Yi Zhou, Zhen Zhang, Junzhen Fan, Feng Liu, Zhang‐Jie Shi
Abstract
Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this paper, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.
Topics & Concepts
Intramolecular forceChemistryArylOxidative coupling of methaneTetralinOxidative additionOxidative phosphorylationCombinatorial chemistryCoupling (piping)CatalysisStereochemistryOrganic chemistryAlkylMechanical engineeringBiochemistryEngineeringCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions