Resveratrol reduces gentamicin-induced EMT in the kidney via inhibition of reactive oxygen species and involving TGF-β/Smad pathway
Olivia N. Beshay, Mohamed G. Ewees, Mohamed S. Abdel‐Bakky, Sara Mohamed Naguib Abdel Hafez, Amany B. Abdelrehim, Asmaa M. A. Bayoumi
Topics & Concepts
NephrotoxicitySMADOxidative stressKidneyPharmacologyResveratrolChemistryReactive oxygen speciesCatalaseMalondialdehydeAminoglycosideIntraperitoneal injectionEpithelial–mesenchymal transitionGlutathioneTransforming growth factorSignal transductionInternal medicineBiologyMedicineBiochemistryAntibioticsDownregulation and upregulationEnzymeGeneAntibiotics Pharmacokinetics and EfficacyNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects