Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting
Pascal Chappert, François Huetz, Marie‐Alix Espinasse, Fabrice Chatonnet, Louise Pannetier, Lucie Da Silva, Clara Goetz, Jérôme Megret, Aurélien Sokal, Étienne Crickx, Ivan Nemazanyy, Vincent Jung, Ida Chiara Guerrera, Sébastien Storck, Matthieu Mahévas, Antonio Cosma, Patrick Revy, Thierry Fest, Claude–Agnès Reynaud, Jean–Claude Weill
Topics & Concepts
BiologyGerminal centerTelomereNegative selectionMemory B cellSpleenMarginal zoneLongevityVacciniaB cellPhenotypeNicheImmunologyImmune systemGeneticsVirologyAntibodyGeneGenomeEcologyRecombinant DNAT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesSingle-cell and spatial transcriptomics