Metabolically targeting immunosuppression and immunoescape for future cancer immunotherapy: a narrative review
Bo Huang, Xuetao Cao
Abstract
Abstract Cancer immunotherapy has emerged as the most important new approach to cancer treatments and moved rapidly to front-line therapy for certain types of cancers. However, both tumor microenvironments and tumor cells can mediate immunosuppression and immunoescape, thus dampening the efficacy of immunotherapy. Despite the complicacies, mechanistic illuminations of unknown immunosuppression and immunoescape are of paramount importance. This short review highlights the recent important findings in cancer immunology and immunotherapy, thus providing new insights into cancer immunosuppression, immunoescape and contributing to the design of innovative immunotherapeutics.
Topics & Concepts
ImmunosuppressionImmunotherapyCancer immunotherapyCancerMedicineImmunologyNarrative reviewImmune systemInternal medicineIntensive care medicineCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses