Ligand Enabled Pd(II)-Catalyzed γ-C(sp<sup>3</sup>)–H Lactamization of Native Amides
Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap‐Sun Yeung, Shun Su, Emily C. Cherney, Zheming Ruan, William R. Ewing, Michael A. Poss, Jin‐Quan Yu
Abstract
-butyl hydrogen peroxide (TBHP) as the sole bystanding oxidant, and a broad substrate scope. The utility of this protocol was demonstrated through the two-step syntheses of a lenalidomide analog and brivaracetam from readily available carboxylic acids and amino acids.
Topics & Concepts
ChemistryCatalysisLigand (biochemistry)StereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsHistone Deacetylase Inhibitors ResearchSynthesis and Catalytic Reactions