POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
Karl P. Hodel, Meijuan J.S. Sun, Nathan Ungerleider, Vivian S. Park, Leonard G. Williams, David L. Bauer, Victoria E. Immethun, Jieqiong Wang, Zucai Suo, Hua Lu, James B. McLachlan, Zachary F. Pursell
Topics & Concepts
BiologyGeneticsMutationDNA mismatch repairMutagenesisMutantExonucleasePopulationMutation rateAlleleGeneDNA repairMolecular biologyDNA polymeraseSociologyDemographyCancer Genomics and DiagnosticsDNA Repair MechanismsGenetic factors in colorectal cancer