Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation
Yanguo Shang, Qingjing Hao, Kaixuan Jiang, Mengting He, Jinxin Wang
Topics & Concepts
ChemistryFatty acid amide hydrolaseNeuroinflammationDocking (animal)PharmacologyCarbohydrazideIC50Lead compoundStructure–activity relationshipStereochemistryBiochemistryCombinatorial chemistryInflammationIn vitroAntagonistOrganic chemistryReceptorCannabinoid receptorNursingInternal medicineMedicineCannabis and Cannabinoid ResearchPharmacological Receptor Mechanisms and EffectsTryptophan and brain disorders