Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies
Dawid Panek, Anna Pasieka, Gniewomir Latacz, Paula Zaręba, Michał Szczęch, Justyna Godyń, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Maria Walczak, Magdalena Smolik, Kinga Sałat, Georg Höfner, Klaus T. Wanner, Anna Więckowska, Barbara Malawska
Topics & Concepts
In vivoChemistryPharmacologyButyrylcholinesterasehERGIn vitroLead compoundPharmacokineticsStereochemistryBiochemistryAchéEnzymeAcetylcholinesteraseInternal medicineMedicinePotassium channelBiologyBiotechnologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsChemical synthesis and alkaloids