Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer
Xue Dong, Pei Pan, Diwei Zheng, Peng Bao, Xuan Zeng, Xian‐Zheng Zhang
Abstract
in gut and lead to reduction in MDSC amplification in the tumor site. In addition, antigen-presenting cells (APCs) were activated by M13 phages to further awaken the host immune system for CRC suppression. M13@Ag combined with immune checkpoint inhibitors (α-PD1) or chemotherapeutics (FOLFIRI) significantly prolonged overall mouse survival in the orthotopic CRC model.
Topics & Concepts
Immune systemTumor microenvironmentCancer researchBiologyColorectal cancerIn vivoCancerCarcinogenesisFusobacterium nucleatumMicrobiologyImmunologyBacteriaPorphyromonas gingivalisGeneticsBiotechnologyBacteriophages and microbial interactionsCancer Research and TreatmentsGut microbiota and health