A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans
Judun Zheng, Qiuqiang Zhan, Lijun Jiang, Da Xing, Tao Zhang, Ka‐Leung Wong
Abstract
A terbium complex <bold>Tb-1</bold> was demonstrated to undergo bioorthogonal ligation with engineered cell-surface glycans, which results in a much less efficient LRET and a 5-fold increase in long-lived terbium emission with low toxicity.
Topics & Concepts
Bioorthogonal chemistryGlycanTerbiumLabellingChemistryCombinatorial chemistryBiochemistryClick chemistryOrganic chemistryIonGlycoproteinClick Chemistry and ApplicationsRadiopharmaceutical Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniques