Sn(OTf)<sub>2</sub>-Catalyzed (3 + 2) Cycloaddition/Sulfur Rearrangement Reaction of Donor–Acceptor Cyclopropanes with Indoline-2-thiones
Yan Jiang, Haojie Ma, Chen-Ying Zhai, Xuelong Wang
Abstract
The (3 + 2) cycloaddition/sulfur rearrangement reaction of donor–acceptor cyclopropanes bearing a single keto acceptor with indoline-2-thiones has been realized. Under the catalysis of Sn(OTf) 2, a series of functionalized 3-indolyl - 4,5-dihydrothiophenes were synthesized with moderate to excellent yields.
Topics & Concepts
IndolineChemistryCycloadditionCatalysisSulfurAcceptorMedicinal chemistryOrganic chemistryPhysicsCondensed matter physicsCyclopropane Reaction MechanismsSulfur-Based Synthesis TechniquesCatalytic Alkyne Reactions