Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
Hua Yu, Tiezhu Shi, Linli Yao, Dongwei Xu, Yufeng Ding, Qiang Xia, Wei Liu, Xiongjun Wang
Topics & Concepts
Cancer researchTumor microenvironmentBiologyBlockadeImmune checkpointMedicineImmune systemImmunotherapyImmunologyInternal medicineReceptorTumor cellsImmune cells in cancerCancer Immunotherapy and BiomarkersProtein Degradation and Inhibitors