A photoinduced transient activating strategy for late-stage chemoselective C(sp<sup>3</sup>)–H trifluoromethylation of azines
Mengjun Huang, Jiawei Ma, Zhenlei Zou, Heyin Li, Jiyang Liu, Lingyu Kong, Yi Pan, Weigang Zhang, Yong Liang, Yi Wang
Abstract
Late-stage C(sp 3 )–H functionalization of unactivated azines: the traceless Tf switching process offers ample opportunities for site-selective derivatization of heteroaryls, allowing for the rapid increase of molecular complexity.
Topics & Concepts
TrifluoromethylationTransient (computer programming)ChemistryStage (stratigraphy)PhotochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryComputer scienceTrifluoromethylOperating systemBiologyPaleontologyAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions