Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism
Hongyu Qin, Jiamin Yu, Huan Yu, Chuqiao Zhou, Dongfeng Yuan, Ziling Wang, Zhenglin Zhu, Guizheng Wei, Peiyan Ou, Z. Li, Hua Jiang, Jie Shen, Guozhi Xiao, Xiaochun Bai, Huaiyu Wang, Huan‐Tian Zhang, John R. Speakman, Di Chen, Liping Tong
Topics & Concepts
OsteoarthritisSemaglutideMedicineWeight lossMediatorInternal medicineArthritisCartilageBioinformaticsMechanism (biology)Therapeutic approachEndocrinologyPharmacologyInflammationChondrocytePathologicalMetabolic disorderAppetiteOxidative phosphorylationEnergy metabolismGlycolysisOxidative stressCancer researchMetabolic diseaseBody weightReceptorWeight managementClinical trialTherapeutic effectArticular cartilageCarbohydrate metabolismLipid metabolismAnimal studiesDiabetes Treatment and ManagementOsteoarthritis Treatment and MechanismsPain Mechanisms and Treatments