Activation of adenosine A <sub>2A</sub> receptor by lipids from docosahexaenoic acid revealed by NMR
Takuya Mizumura, Keita Kondo, Masatoshi Kurita, Yutaka Kofuku, Mei Natsume, Shunsuke Imai, Yutaro Shiraishi, Takumi Ueda, Ichio Shimada
Abstract
NMR studies of A 2A AR in lipid bilayers of nanodiscs revealed the mechanism underlying activation of A 2A AR by DHA chains.
Topics & Concepts
Docosahexaenoic acidChemistryBiophysicsAdenosineMechanism (biology)Lipid bilayerBiochemistryFatty acidMembraneBiologyPolyunsaturated fatty acidPhysicsQuantum mechanicsReceptor Mechanisms and SignalingLipid Membrane Structure and BehaviorAdenosine and Purinergic Signaling