Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization
Jiahui Li, Mengxue Yu, Ruobin Zong, Chengpeng Fan, Fu Ren, Wei Wu, Changyong Li
Abstract
This study identified a previously unrecognized molecular mechanism of HBV-mediated suppression of innate immune responses. We demonstrate that deacetylation of NICD by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization, which may aid in the development of new macrophage-based immunotherapy for chronic HBV infection and related diseases.
Topics & Concepts
Macrophage polarizationHBsAgHepatitis B viruscccDNAImmune systemTumor necrosis factor alphaImmunologyProinflammatory cytokineBiologyMacrophageVirologyCancer researchInflammationVirusIn vitroBiochemistryHepatitis B Virus StudiesHIV Research and TreatmentAutophagy in Disease and Therapy