E-cadherin on epithelial–mesenchymal transition in thyroid cancer
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng
Abstract
Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy and invasion. One key change in tumour EMT is low expression of E-cadherin. Therefore, this article reviews the expression of E-cadherin in thyroid cancers (TC), discuss the potential mechanisms involved, and outline opportunities to exploit E-cadherin on regulating the occurrence of EMT as a critical factor in cancer therapeutics.
Topics & Concepts
Epithelial–mesenchymal transitionMalignancyCadherinMedicineMetastasisThyroid cancerCancer researchThyroidCancerThyroid carcinomaEndocrine systemHead and neckSlugPathologyOncologyBioinformaticsInternal medicineBiologyHormoneCellSurgeryGeneticsWnt/β-catenin signaling in development and cancerCancer Cells and MetastasisCancer-related gene regulation