Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532
Fumihito Ushiyama, Hajime Takashima, Yohei Matsuda, Yuya Ogata, Naoki Sasamoto, Risa Kurimoto-Tsuruta, Kaori Ueki, Nozomi Tanaka-Yamamoto, Mayumi Endo, Masashi Mima, Kiyoko Fujita, Iichiro Takata, Satoshi Tsuji, Haruhiro Yamashita, Hirotoshi Okumura, Katsumasa Otake, Hiroyuki Sugiyama
Topics & Concepts
ChemistryKlebsiella pneumoniaeHydroxymethylPharmacologyDrugBacteriaMoietyEscherichia coliBiochemistryStereochemistryBiologyGeneticsGeneAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentPneumonia and Respiratory Infections